Genetic resistance of methicillin-resistant Staphylococcus aureus: a review
DOI:
https://doi.org/10.61182/rnavmed.v6n2a3Keywords:
Staphylococcus aureus Resistant to Methicillin, Infection, GeneAbstract
Resistance to beta-lactams is produced by a genetic component called chromosomal cassette mec (SSCmec). This encodes the protein PBP2a (Penicillin binding protein 2a), responsible for producing changes in the conformation of peptidoglycans, destined to integrate into the cell membrane. This mechanism of antibiotic resistance generates high mortality in hospitalized patients, especially in those in the Intensive Care Unit (ICU), due to the pharmacological arsenal used. The present work reviews the literature in databases such as Clinicalkey, OVID, PuBMED Central, BVS, SCIELO, Science Direct and the Cochrane Library, between 2010 and 2020. Although the worldwide literature agrees that methicillin-resistant Staphylococcus aureus (MRSA) is a pathogenic agent and a microorganism with a high prevalence in patients with nosocomial infections, an adequate study for each case will determine a better therapeutic management of this infection.
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