Amyotrophic Lateral Sclerosis, forgotten symptoms: case report

Authors

DOI:

https://doi.org/10.61182/rnavmed.v11n2a4

Keywords:

Amyotrophic lateral sclerosis, neurodegenerative disease, upper motor neuron syndrome, lower motor neuron syndrome

Abstract

Amyotrophic lateral sclerosis (ALS) is characterized by being a neurological pathology with progressive neurodegenerative compromise in first and second motor neurons at the pyramidal pathway, markedly producing muscle weakness and motor disability. It can present a non-motor compromise in up to 50% of patients at the time of diagnosis, such as changes in behavior, cognitive alteration, autonomic symptoms, alterations in swallowing, voice and parkinsonism. We present the clinical case of female 70-year-old patient in whom a suspicion of ALS is made during an outpatient consultation of the neurology service with subsequent confirmation of the diagnosis with electrodiagnostic studies.

Author Biographies

  • Ferney Samuel Contento-Anaya, Universidad del Sinú.

    Internal Medicine Resident, Universidad del Sinú.

  • Mario Enrique Montoya-Jaramillo, Universidad del Sinú.

    Internal Medicine Program Director, Universidad del Sinú.

  • Elizabeth Avendaño-Arango, Universidad del Sinú.

    Neurology Resident, Universidad del Sinú.

  • David Fernando Ortiz-Pérez, Universidad del Sinú.

    Internal Medicine Resident, Universidad del Sinú.

  • Edgard Eliud Castillo-Támara, Universidad del Sinú.

    Neurology Program Director, Universidad del Sinú.

References

1. Izenberg A. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases. Continuum (Minneap Minn). 2023;29(5):1538-63. doi: https://doi.org/10.1212/CON.0000000000001345

2. Van Es MA, Amyotrophic lateral sclerosis; clinical features, differential diagnosis and pathology. Int Rev Neurobiol. 2024;176:1-47. doi: https://doi.org/10.1016/BS.IRN.2024.04.011

3. Masrori P, Van Damme P. Amyotrophic lateral sclerosis: a clinical review. Eur J Neurol. 2020; 27(10):1918-29. doi: https://doi.org/10.1111/ene.14393

4. Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ, et al. Amyotrophic lateral sclerosis. Lancet. 2022;400(10360):1363-80. doi: https://doi.org/10.1016/S0140-6736(22)01272-7

5. Goutman SA. Diagnosis and clinical management of amyotrophic lateral sclerosis and other motor neuron disorders. Continuum (Minneap Minn). 2017;23(5):1332-59. doi: https://doi.org/10.1212/CON.0000000000000535

6. Richards D, Morren JA, Pioro EP. Time to diagnosis and factors affecting diagnostic delay in amyotrophic lateral sclerosis. J Neurol Sci. 2020;417:117054. doi: https://doi.org/10.1016/j.jns.2020.117054

7. Riva N, Domi T, Pozzi L, Lunetta C, Schito P, Spinelli EG, et al. Update on recent advances in amyotrophic lateral sclerosis. J Neurol. 2024;271(7):4693-723. doi: https://doi.org/10.1007/s00415-024-12435-9

8. Zapata-Zapata CH, Franco-Dáger E, Solano-Atehortúa JM, Ahunca-Velásquez LF. Esclerosis lateral amiotrófica: actualización. Iatreia. 2016;29(2):194–205. doi: https://doi.org/10.17533/udea.iatreia.v29n2a08

9. Mead RJ, Shan N, Reiser HJ, Marshall F, Shaw PJ. Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation. Nat Rev Drug Discov. 2023;22(3): 185-212. doi: https://doi.org/10.1038/s41573-022-00612-2

10. Tenorio-Pacheco A. Esclerosis Lateral amiotrófica, reto diagnóstico: presentación de un caso clínico. Rev Sanid Milit. 2021;75(3):1-9. doi: https://doi.org/10.56443/rsm.v75i3.230

11. Galvin M, Ryan P, Maguire S, Heverin M, Madden C, Vajda A, et al. The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: a population-based study of consultations, interventions and costs. PLoS One. 2017;12(6):e0179796. doi: https://doi.org/10.1371/journal.pone.0179796

12. Ilieva H, Vullaganti M, Kwan J. Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis. BMJ. 2023;383:e075037. doi: https://doi.org/10.1136/bmj-2023-075037

13. Bucheli ME, Campos M, Bermudes DB, Chuquimarca JP, Sambache K, Cheverrez K, et al. Esclerosis Lateral Amiotrófica: Criterios de El Escorial y la Electromiografía en su Temprano Diagnóstico. Rev Ecuator Neurol. 2012;21(1-3): 61-8.

14. Hatcher-Martin JM, Busis NA, Cohen BH, Wolf RA, Jones EC, Anderson ER, et al. American Academy of Neurology Telehealth Position Statement. Neurology. 2021; 97(7):334-39. doi: https://doi.org/10.1212/WNL.0000000000012185

15. Bradford D, Rodgers KE. Advancements and challenges in amyotrophic lateral sclerosis. Front Neurosci. 2024; 18:1401706. doi: https://doi.org/10.3389/fnins.2024.1401706

Downloads

Published

2025-11-27

Data Availability Statement

 los autores/as han puesto a disposición del público los datos de la investigación 

How to Cite

1.
Contento-Anaya FS, Montoya-Jaramillo ME, Avendaño-Arango E, Ortiz Pérez DF, Castillo-Támara EE. Amyotrophic Lateral Sclerosis, forgotten symptoms: case report. Rev. Navar. Medica [Internet]. 2025 Nov. 27 [cited 2025 Nov. 27];11(2). Available from: https://journals.uninavarra.edu.co/index.php/navarramedica/article/view/45-49

Most read articles by the same author(s)

Similar Articles

1-10 of 49

You may also start an advanced similarity search for this article.